981 research outputs found

    Controlling extended systems with spatially filtered, time-delayed feedback

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    We investigate a control technique for spatially extended systems combining spatial filtering with a previously studied form of time-delay feedback. The scheme is naturally suited to real-time control of optical systems. We apply the control scheme to a model of a transversely extended semiconductor laser in which a desirable, coherent traveling wave state exists, but is a member of a nowhere stable family. Our scheme stabilizes this state, and directs the system towards it from realistic, distant and noisy initial conditions. As confirmed by numerical simulation, a linear stability analysis about the controlled state accurately predicts when the scheme is successful, and illustrates some key features of the control including the individual merit of, and interplay between, the spatial and temporal degrees of freedom in the control.Comment: 9 pages REVTeX including 7 PostScript figures. To appear in Physical Review

    Umbilical Cord Blood and Type 1 Diabetes: A road ahead or dead end?

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    The critical properties of the agent-based model with environmental-economic interactions

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    The steady-state and nonequilibrium properties of the model of environmental-economic interactions are studied. The interacting heterogeneous agents are simulated on the platform of the emission dynamics of cellular automaton. The model possess the discontinuous transition between the safe and catastrophic ecology. Right at the critical line, the broad-scale power-law distributions of emission rates have been identified. Their relationship to Zipf's law and models of self-organized criticality is discussed.Comment: 12 pages, 6 figures, published in Physica

    Time-delayed feedback control in astrodynamics

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    In this paper we present time-delayed feedback control (TDFC) for the purpose of autonomously driving trajectories of nonlinear systems into periodic orbits. As the generation of periodic orbits is a major component of many problems in astodynamics we propose this method as a useful tool in such applications. To motivate the use of this method we apply it to a number of well known problems in the astrodynamics literature. Firstly, TDFC is applied to control in the chaotic attitude motion of an asymmetric satellite in an elliptical orbit. Secondly, we apply TDFC to the problem of maintaining a spacecraft in a periodic orbit about a body with large ellipticity (such as an asteroid) and finally, we apply TDFC to eliminate the drift between two satellites in low Earth orbits to ensure their relative motion is bounded

    Unconventional Josephson Effect in Hybrid Superconductor-Topological Insulator Devices

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    We report on transport properties of Josephson junctions in hybrid superconducting-topological insulator devices, which show two striking departures from the common Josephson junction behavior: a characteristic energy that scales inversely with the width of the junction, and a low characteristic magnetic field for suppressing supercurrent. To explain these effects, we propose a phenomenological model which expands on the existing theory for topological insulator Josephson junctions

    Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria

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    The tight junction proteins claudin-10 and -16 are crucial for the paracellular reabsorption of cations along the thick ascending limb of Henle's loop in the kidney. In patients, mutations in CLDN16 cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis, while mutations in CLDN10 impair kidney function. Mice lacking claudin-16 display magnesium and calcium wasting, whereas absence of claudin-10 results in hypermagnesemia and interstitial nephrocalcinosis. In order to study the functional interdependence of claudin-10 and -16 we generated double-deficient mice. These mice had normal serum magnesium and urinary excretion of magnesium and calcium and showed polyuria and sodium retention at the expense of increased renal potassium excretion, but no nephrocalcinosis. Isolated thick ascending limb tubules of double mutants displayed a complete loss of paracellular cation selectivity and functionality. Mice lacking both claudin-10 and -16 in the thick ascending limb recruited downstream compensatory mechanisms and showed hypertrophic distal convoluted tubules with changes in gene expression and phosphorylation of ion transporters in this segment, presumably triggered by the mild decrease in serum potassium. Thus, severe individual phenotypes in claudin-10 and claudin-16 knockout mice are corrected by the additional deletion of the other claudin

    Liquid racism and the Danish Prophet Muhammad cartoons

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    This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Author.This article examines reactions to the October 2005 publication of the Prophet Muhammad cartoons in the Danish newspaper Jyllands-Posten. It does so by using the concept of ‘liquid racism’. While the controversy arose because it is considered blasphemous by many Muslims to create images of the Prophet Muhammad, the article argues that the meaning of the cartoons is multidimensional, that their analysis is significantly more complex than most commentators acknowledge, and that this complexity can best be addressed via the concept of liquid racism. The article examines the liquidity of the cartoons in relation to four readings. These see the cartoons as: (1) a criticism of Islamic fundamentalism; (2) blasphemous images; (3) Islamophobic and racist; and (4) satire and a defence of freedom of speech. Finally, the relationship between postmodernity and the rise of fundamentalism is discussed because the cartoons, reactions to them, and Islamic fundamentalism, all contain an important postmodern dimension.ESR

    Introduction to topological superconductivity and Majorana fermions

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    This short review article provides a pedagogical introduction to the rapidly growing research field of Majorana fermions in topological superconductors. We first discuss in some details the simplest "toy model" in which Majoranas appear, namely a one-dimensional tight-binding representation of a p-wave superconductor, introduced more than ten years ago by Kitaev. We then give a general introduction to the remarkable properties of Majorana fermions in condensed matter systems, such as their intrinsically non-local nature and exotic exchange statistics, and explain why these quasiparticles are suspected to be especially well suited for low-decoherence quantum information processing. We also discuss the experimentally promising (and perhaps already successfully realized) possibility of creating topological superconductors using semiconductors with strong spin-orbit coupling, proximity-coupled to standard s-wave superconductors and exposed to a magnetic field. The goal is to provide an introduction to the subject for experimentalists or theorists who are new to the field, focusing on the aspects which are most important for understanding the basic physics. The text should be accessible for readers with a basic understanding of quantum mechanics and second quantization, and does not require knowledge of quantum field theory or topological states of matter.Comment: 21 pages, 5 figure

    Quantification of FAM20A in human milk and identification of calcium metabolism proteins

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    BACKGROUND: FAM20A, a recently discovered protein, is thought to have a fundamental role in inhibiting ectopic calcification. Several studies have demonstrated that variants of FAM20A are causative for the rare autosomal recessive disorder, enamel-renal syndrome (ERS). ERS is characterized by defective mineralization of dental enamel and nephrocalcinosis suggesting that FAM20A is an extracellular matrix protein, dysfunction of which causes calcification of the secretory epithelial tissues. FAM20A is a low-abundant protein that is difficult to detect in biofluids such as blood, saliva, and urine. Thus, we speculated the abundance of FAM20A to be high in human milk, since the secretory epithelium of lactating mammary tissue is involved in the secretion of highly concentrated calcium. Therefore, the primary aim of this research is to describe the processes/methodology taken to quantify FAM20A in human milk and identify other proteins involved in calcium metabolism. METHOD: This study used mass spectrometry-driven quantitative proteomics: (1) to quantify FAM20A in human milk of three women and (2) to identify proteins associated with calcium regulation by bioinformatic analyses on whole and milk fat globule membrane fractions. RESULTS: Shotgun MS/MS driven proteomics identified FAM20A in whole milk, and subsequent analysis using targeted proteomics also successfully quantified FAM20A in all samples. Combination of sample preparation, fractionation, and LC-MS/MS proteomics analysis generated 136 proteins previously undiscovered in human milk; 21 of these appear to be associated with calcium metabolism. CONCLUSION: Using mass spectrometry-driven proteomics, we successfully quantified FAM20A from transitional to mature milk and obtained a list of proteins involved in calcium metabolism. Furthermore, we show the value of using a combination of both shotgun and targeted driven proteomics for the identification of this low abundant protein in human milk
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